Cordiart® is a natural Citrus sinensis extract from sweet oranges, supporting healthy circulation. A clinical study has shown the beneficial effect of Cordiart® on endothelial function, inflammatory status and metabolic parameters.
Citrus sinensis extract for blood flow
Cordiart® is water-extracted from sweet organes grown in the Mediterranean region. It is standardized for 90% hesperidin and micronized for enhanced bioavailability.
Cardiovascular health
Blood flow
Plaque formation
Clinically validated
Daily dose 500mg
Endothelial function: Key to cardiovascular health
Blood vessels are the interface between blood and body, and permit transport of nutrients to cells in the body. The inner lining of the blood vessel, the endothelium, plays a critical role in the maintenance of healthy arteries. With ageing, lifestyle and inflammation, blood vessels become rigid. When the endothelium is not functioning properly, blood vessels lose the ability to fully dilate in response to a change in blood flow and attract more fat deposits and inflammatory cells, a state called endothelial dysfunction. Endothelial dysfunction is recognized as a major factor in the development of cardiovascular disease (CVD) like atherosclerosis, hypertension and heart failure.
Nitric Oxide (NO): protector of vascular health
Endothelial dysfunction is commonly associated with decreased Nitric Oxide (NO) bioavailability, due to impaired NO production by the endothelium. NO is a crucial molecule for the maintenance of vascular health. It largely mediates vasodilation, inhibition of inflammation and inhibition of platelet adherence and aggregation.
Clinically proven benefits
A randomized placebo-controlled trial (n=68) was executed to investigate the effects of 500mg Cordiart® versus placebo on Flow Mediated Dilated (FMD). Supplementation of 6 weeks resulted in a significant increase in FMD, a significant decrease in adhesion molecules sICAM-1 and sVCAM-1, and a significant reduction in blood pressure.
Mode of action
Cordiart® exerts its beneficial effects on three levels:
1. Vascular endothelium: activation of eNOS increases the production of Nitric Oxide (NO) by the endothelium. This in turn stimulates vasodilation and blood flow.
2. Decrease of lipid accumulation within pre-adipocytes reduces vascular inflammation and endothelial dysfunction.
3. Arterial flexibility: decrease of adhesion molecules sVCAM-1 and sICAM-1, which are markers of plaque formation.
Applications and NPD
Cordiart® is a great addition to any product that targets cardiovascular health. It has a neutral taste and is easily combined with L-arginin, vitamin K, vitamin D and folic acid.
Capsules
Powder blend
Soft-gels
Researched & developed by Solabia Nutrition
Cordiart® was researched and developed by Solabia Nutrition, a life science company that develops health ingredients for functional foods, clinical nutrition and dietary supplements.
Solabia Nutrition focuses on the core mission of bringing nutritional products backed up by real science to consumers, helping them perform better and improve their health and well-being.
Find out more about Solabia Nutrition, visit the website
Find out more about the sustainable way we use immature oranges for our citrus extracts